Why the study?
How does the removal of circulating noradrenaline differ between pulmonary and systemic vascular beds in healthy young men?
Population
Unanaesthetized, healthy young men
Comparison
Injection of a mixture of 3H-NA with 14C-inulin… vs Comparison between pulmonary and forearm…
Design
Other
Follow-up
Acute
Authors
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Noradrenaline extraction differs by vascular bed in healthy men; hypothesis-generating for physiology but should not yet change practice.
How does the removal of circulating noradrenaline differ between pulmonary and systemic vascular beds in healthy young men?
Circulating noradrenaline is removed via specific trapping in the systemic vascular bed (forearm) but initially via unspecific filtration/diffusion in the pulmonary vascular bed.
Stjärne et al. (1975) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: