Human peripheral blood mononuclear cells show after one day of culture with opsonized zymosan a decreased expression of HLA-DR (but not HLA-A, B, C) antigens, which can be prevented by the scavenger of reactive oxygen intermediates beta-carotene, or superoxide dismutase or indomethacin. Mononuclear cells of a patient with a heterozygous form of chronic granulomatous disease show no alterations in HLA-DR antigen expression after culture with opsonized zymosan. Possible roles of reactive oxygen intermediates or prostaglandins in the modulation of HLA-DR antigens are discussed.
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Grüner et al. (1986) studied this question.
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