Regioselective Bromomethylation of 1,2-Dialkylbenzenes

All articles of this category This paper describes a systematic exploration of the regioselective bromomethylation of 1,2-dialkylbenzenes as a function of the reaction temperature and the chain length of the alkyl groups. At both 80 and 110 °C, bromomethyl groups can be introduced into the 4 and 5 positions of 1,2-dialkylbenzenes with high selectivity when the alkyl chains consist of two or more carbon atoms. regioselective - aromatic - bromomethylation - 1,2-dialkylbenzenes - 1,2,4,5-tetrasubstitution