Key result
Oral dysbiosis is linked to cryptogenic ischemic stroke in patients with high-risk PFO.
Why the study?
Are there differences in the oral microbiome between young-onset cryptogenic ischemic stroke patients with high-risk PFO, those without PFO, and stroke-free controls with high-risk PFO?
Observational (n=120)
Are there differences in the oral microbiome between young-onset cryptogenic ischemic stroke patients with high-risk PFO, those without PFO, and stroke-free controls with high-risk PFO?
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Oral microbiome dysbiosis may be an under-recognized contributing factor in the etiology of cryptogenic ischemic stroke associated with high-risk PFO.
Manzoor et al. (2025) conducted an observational in Cryptogenic ischemic stroke (n=120). High-risk patent foramen ovale vs. Patients without PFO and stroke-free controls was evaluated on Oral microbiome beta diversity and taxonomic abundance. Oral microbiome beta diversity differed significantly between cryptogenic ischemic stroke patients and stroke-free controls with high-risk PFO, suggesting a role for oral dysbiosis.
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