Population
16 dogs and postmortem material from 8 patients with infarct extension.
Comparison
40-minute temporary occlusion of the left… vs Ventilation with room air.
Design
Preclinical
Follow-up
24 hours (for reocclusion phase)
Authors
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Hyperoxia enlarges the preserved subendocardial zone after transient occlusion in dogs; leaves open whether oxygen supplementation limits infarct extension in patients.
A preserved subendocardial zone exists after temporary coronary occlusion, likely maintained by diffusion from the ventricular cavity, but this region remains susceptible to infarct extension upon permanent occlusion.
Forman et al. (1983) studied this question.
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