Renal dye dilution curves are constantly influenced by recirculating dye, with early deviation from linear extrapolation potentially due to inadequate mixing, extravascular leakage, or medullary circulation.
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May affect renal dye dilution interpretation; leaves open mechanisms of early deviation from linear extrapolation.
The dye dilution curves from twelve human kidneys were compared with systemic curves from the same individuals recorded at the same time. The recirculation distance was the same for both types of recording.The renal curves were constantly influenced by recirculating dye. The initial deviation from the linear semilogarithmic extrapolation of the down slope of the renal curves occurred before the minimal re-circulation time and could be caused by inadequate mixing of dye in the renal artery, leakage of dye into the extravascular space or by the medullary circulation.
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Ofstad et al. (1967) studied this question.
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