Why the study?
Does calcium channel blockade and sex hormone suppression prevent recurrent NSTEMI in a patient with catamenial coronary artery spasm?
Does calcium channel blockade and sex hormone suppression prevent recurrent NSTEMI in a patient with catamenial coronary artery spasm?
Catamenial coronary artery spasm is a rare but important cause of MINOCA that can be effectively treated with calcium channel blockers and hormonal suppression.
Menstrual-timed recurrent NSTEMI may reflect hormonal spasm triggers; hypothesis-generating for cycle-specific testing in premenopausal MINOCA.
Background: Coronary artery spasm is an established mechanism of myocardial infarction with non-obstructive coronary arteries (MINOCA). Various mechanisms have been proposed, ranging from vascular smooth muscle hyperreactivity to endothelial dysfunction, to autonomic nervous system dysregulation. Case summary: We report a case of a 37-year-old woman who presented with recurrent non-ST elevation myocardial infarction (NSTEMI), coinciding with her menstrual periods. Intracoronary acetylcholine provocation testing resulted in coronary spasm in the left anterior descending artery (LAD) that was relieved with nitroglycerine. Initiating calcium channel blockade and suppressing cyclical variation in sex hormones resulted in improvement of her symptoms and cessation of monthly NSTEMI events due to coronary spasm. Discussion: Initiating calcium channel blockade and suppressing cyclical variation in sex hormones resulted in improvement of her symptoms and cessation of monthly NSTEMI events due to coronary spasm. Catamenial coronary artery spasm is a rare, but clinically important, presentation of myocardial infarction with non-obstructive coronary arteries (MINOCA).
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Talmor et al. (2023) studied this question.
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