Impact of personal and ambient-level exposures to nitrogen dioxide and particulate matter on cardiovascular function

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Cardiovascular function in relation to air pollution exposure (n=65). Intervention: Personal and ambient exposures to nitrogen dioxide (NO2) and PM2.5 components (including potassium). Primary outcome: Changes in cardiovascular function including systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), brachial artery diameter (BAD), flow-mediated dilatation (FMD), and nitroglycerin-mediated arterial dilatation (NMD) (DBP: -0.0447 ± 0.0132 mmHg/ng/m3 (potassium, lag 0); BAD: 0.0041 ± 0.0019 mm/ppb (NO2, lag 1); FMD: 0.0612 ± 0.0235 (NO2, lag 0), p=0.0016 (DBP); 0.0353 (BAD); 0.0103 (FMD)).

Q: What does this research mean for the field?

Personal exposure to nitrogen dioxide alters vascular endothelial function, and airborne particulate potassium exposure is associated with reduced diastolic blood pressure in non-smoking adults. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ron Williams; Robert D. Brook; Robert L. Bard; Teri Conner; Hwashin Hyun Shin; Richard T. Burnett

doi:10.1080/09603123.2011.588437

June 28, 2011International Journal of Environmental Health Research

Impact of personal and ambient-level exposures to nitrogen dioxide and particulate matter on cardiovascular function

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Key result

Personal NO2 exposure impairs vascular function, while airborne potassium is linked to lower diastolic BP.

DBP: -0.0447 ± 0.0132 mmHg/ng/m3 (potassium, lag 0); BAD: 0.0041 ± 0.0019 mm/ppb (NO2, lag 1); FMD: 0.0612 ± 0.0235 (NO2, lag 0)
P=0.0016 (DBP); 0.0353 (BAD); 0.0103 (FMD)
n=65

Study Design

Type

Cohort (n=65)

Multicenter

No

PICO

P

Population

65 adult non-smoking volunteers from the Detroit Exposure and Aerosol Research Study (DEARS) evaluated with up to 336 daily environmental and in-home cardiovascular observations.

E

Exposure / Comparator

Personal and ambient exposures to nitrogen dioxide (NO2) and PM2.5 components (including potassium)

O

Primary Outcome

Changes in cardiovascular function including systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), brachial artery diameter (BAD), flow-mediated dilatation (FMD), and nitroglycerin-mediated arterial dilatation (NMD) — DBP: -0.0447 ± 0.0132 mmHg/ng/m3 (potassium, lag 0); BAD: 0.0041 ± 0.0019 mm/ppb (NO2, lag 1); FMD: 0.0612 ± 0.0235 (NO2, lag 0), p=0.0016 (DBP); 0.0353 (BAD); 0.0103 (FMD)

Main Result

Effect estimate: DBP: -0.0447 ± 0.0132 mmHg/ng/m3 (potassium, lag 0); BAD: 0.0041 ± 0.0019 mm/ppb (NO2, lag 1); FMD: 0.0612 ± 0.0235 (NO2, lag 0)

p-value: p=0.0016 (DBP); 0.0353 (BAD); 0.0103 (FMD)

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Abstract

This work explored the association between nitrogen dioxide (NO(2)) and PM(2.5) components with changes in cardiovascular function in an adult non-smoking cohort. The cohort consisted of 65 volunteers participating in the US EPA's Detroit Exposure and Aerosol Research Study (DEARS) and a University of Michigan cardiovascular sub-study. Systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), brachial artery diameter (BAD), brachial artery flow-mediated dilatation (FMD) and nitroglycerin-mediated arterial dilatation (NMD) were collected by in-home examinations. A maximum of 336 daily environmental and health effect observations were obtained. Daily potassium air concentrations were associated with significant decreases in DBP (-0.0447 mmHg/ng/m(3) ± 0.0132, p = 0.0016, lag day 0) among participants compliant with the personal monitoring protocol. Personal NO(2) exposures resulted in significant changes in BAD (e.g., 0.0041 mm/ppb ± 0.0019, p = 0.0353, lag day 1) and FMD (0.0612 ± 0.0235, p = 0.0103, lag day 0) among other findings.

Discussion

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Cite This Study

Williams et al. (2011) conducted a cohort in Cardiovascular function in relation to air pollution exposure (n=65). Personal and ambient exposures to nitrogen dioxide (NO2) and PM2.5 components (including potassium) was evaluated on Changes in cardiovascular function including systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), brachial artery diameter (BAD), flow-mediated dilatation (FMD), and nitroglycerin-mediated arterial dilatation (NMD) (DBP: -0.0447 ± 0.0132 mmHg/ng/m3 (potassium, lag 0); BAD: 0.0041 ± 0.0019 mm/ppb (NO2, lag 1); FMD: 0.0612 ± 0.0235 (NO2, lag 0), p=0.0016 (DBP); 0.0353 (BAD); 0.0103 (FMD)). Personal NO2 exposure significantly altered brachial artery diameter (0.0041 mm/ppb, p=0.0353) and FMD (p=0.0103), while daily airborne potassium decreased DBP (-0.0447 mmHg/ng/m3, p=0.0016).

synapsesocial.com/papers/6a720cd42163a0a01bc5e912 https://doi.org/10.1080/09603123.2011.588437

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Impact of personal and ambient-level exposures to nitrogen dioxide and particulate matter on cardiovascular function

Study Design

PICO

Main Result

Ask about this paper

Abstract

Discussion

Cite This Study

Impact of personal and ambient-level exposures to nitrogen dioxide and particulate matter on cardiovascular function

Study Design

PICO

Main Result

Ask about this paper

Abstract

Discussion

Cite This Study

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