Key result
VDR Apa-I polymorphism and autoimmune comorbidities are associated with vitiligo in high-consanguinity populations.
Case-Control (n=31)
No
Vitiligo has been associated with the host's genetic profile, metabolic abnormality and immunostatus. The purpose of this study was to investigate the association of vitiligo with autoimmune diseases for 31 out of 39 subjects with vitiligo and their first-degree relatives living in a small Caucasian inbred rural community. They were compared with healthy individuals. A 2.28% prevalence of vitiligo was calculated and the presence of consanguine marriages (72.3%) was noted for this community. Our results indicate an increased prevalence of thyroidopathies, diabetes mellitus and rheumatoid arthritis in families with vitiligo. We also show that the Apa-I polymorphism of the vitamin D receptor gene is associated with vitiligo. This is the first study of its kind performed in Romania suggesting that the vitamin D receptor gene might play a role in the aetiopathogenesis of skin depigmentation.
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Birlea et al. (2006) conducted a case-control in Vitiligo (n=31). Vitamin D receptor gene Apa-I polymorphism and familial autoimmune diseases vs. Healthy individuals was evaluated on Association with vitiligo and prevalence of autoimmune diseases (thyroidopathies, diabetes mellitus, rheumatoid arthritis). VDR Apa-I polymorphism and autoimmune diseases (thyroidopathies, diabetes, RA) were associated with vitiligo in a Romanian community (2.28% vitiligo prevalence, 72.3% consanguinity).
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