Key result
Androgen excess in PCOS independently drives metabolic dysfunction and increases cardiovascular events and CAD risk.
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Polycystic ovary syndrome (PCOS) is associated with a clustering of metabolic and cardiovascular risk factors. Insulin resistance is implicated as the major player in the metabolic abnormalities and contributes to the increased cardiovascular risk associated with the syndrome. However, androgen excess appears to participate as an independent parameter, which further aggravates the cardiovascular and metabolic aberrations in affected women with PCOS. The resultant impact of hyperandrogenemia possibly acquires clinical significance for women's health in the context of PCOS, particularly since recent data support an increased incidence of coronary artery disease and of cardiovascular events directly related to androgen levels in women with the syndrome.
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Christakou et al. (2008) conducted a review in Polycystic ovary syndrome (PCOS). Androgen excess / hyperandrogenemia was evaluated on Metabolic aberrations, coronary artery disease, and cardiovascular events. Androgen excess independently aggravates metabolic and cardiovascular aberrations in women with PCOS, contributing to an increased incidence of coronary artery disease and cardiovascular events.
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