Population
Cultured human umbilical vein endothelial cells
Comparison
Membrane depolarization induced by high… vs Control/baseline conditions
Design
Preclinical
Authors
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Should not alter hypertension management; leaves open Rac as a target in vascular superoxide pathways.
Membrane depolarization stimulates endothelial superoxide production through a tyrosine phosphorylation-dependent translocation of the small G-protein Rac, providing insight into mechanisms of hypertensive vascular hypertrophy.
Sohn et al. (2000) studied this question.
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