Synthesis and In Vitro Cytotoxic Activity of 2‐Amino‐7‐(dimethylamino)‐4‐[(trifluoromethyl)phenyl]‐4H‐chromenes

Three 2‐amino‐4‐(trifluoromethylphenyl)‐3‐cyano‐7‐(dimethylamino) ‐4 H ‐chromene derivatives were synthesized and their cytotoxic activities were determined against six human tumor cell lines using MTT assay. Condensation of 3‐(dimethylamino)phenol, trifluoromethybenzaldehydes and malonitrile in ethanol containing piperidine afforded corresponding chromenes (4a-c) . The structure of the synthesized compound was confirmed by 1 H NMR, IR and Mass spectral data. Among compounds tested, 3‐trifluoromethyl analogue (3b) was the most active against all human tumor cell lines (IC 50 =12‐45 nM).