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September 2, 1997Proceedings of the National Academy of SciencesOpen Access

An intercalation inhibitor altering the target selectivity of DNA damaging agents: Synthesis of site-specific aflatoxin B 1 adducts in a p53 mutational hotspot

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Authors

WKWilliam R. KobertzUniversity of Massachusetts Chan Medical SchoolDWDavid WangUniversity of IowaGWGerald N. WoganRutgers, The State University of New Jersey

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Kobertz et al. (1997) studied this question.

synapsesocial.com/papers/6a7218d078a11c550e0bf5b4https://doi.org/10.1073/pnas.94.18.9579
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNA at positions of guanine and adenine.1978 · 85 citations
  2. 2Calculation of binding isotherms for heterogeneous polymers1968 · 443 citations
  3. 3DNA conformation mediates aflatoxin B1-DNA binding and the formation of guanine N7 adducts by aflatoxin B1 8,9-exo-epoxide1993 · 77 citations
  4. 4Preparation of the 8,9-epoxide of the mycotoxin aflatoxin B1: the ultimate carcinogenic species1988 · 238 citations
  5. 5Identification of the principal aflatoxin B1-DNA adduct formed in vivo in rat liver.1978 · 251 citations