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Literature evidence that natural products are potential bioactive components for lead compounds in drug discovery. These molecules have distinctive chemical structures that play a significant role in identifying and developing drugs for different diseases as therapeutics. Further, natural products have been known for both medicinal and biological activities. One such natural product, luteolin, a wonder molecule, belongs to the class of flavonoids. A dietary flavonoid, luteolin exhibits potent anticancer, antioxidant, anti-inflammatory, and antiviral activities. This review covers comprehensive insight into the anticancer potential and structural activity relationship of luteolin and its analogs. This review also summarizes the recent reports on anticancer activities of luteolin and our earlier work on target-specific p300 inhibitory potential of luteolin and its mimics.
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Basha et al. (2022) studied this question.
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