A single amino acid substitution in the regulatory subunit of myosin significantly impairs flight ability and power output in Drosophila, demonstrating the utility of molecular genetics in integrative biology.
Substituting an alanine for serine in the regulatory subunit of the motor protein myosin dramatically alters Drosophila's flight ability. Power output, at all levels of the flight system, is reduced. This example of deciphering a protein's function by producing malfunctions illustrates the broadening use of molecular genetics in integrative biology.
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Maughan et al. (1999) studied this question.
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