Key result
Emetine and antimony are linked to myocardial toxicity and marked electrocardiographic changes.
Observational
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Demonstrates the cardiotoxic effects of emetine and antimony on the myocardium, highlighting persistent clinical concerns despite therapeutic utility.
A number of drugs have achieved notoriety for their toxicity to the myocardium. Of those used in tropical medicine antimony and emetine are outstanding examples. Both are valuable therapeutic agents and have yet to be supplanted by equally effective yet less toxic drugs. The fact that they affect the electrocardiogram has been known for some years, but there has been a recent renewed interest in the changes produced by antimony in both its older and newer chemical forms (Honey, 1960; Davis, 1961; and Somers and Rosanelli, 1962).
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P Turner (1963) conducted an observational in Myocardial toxicity. Emetine was evaluated on Electrocardiographic and myocardial changes. Emetine and antimony are recognized for their toxicity to the myocardium and their capacity to produce electrocardiographic changes.
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