What question did this study set out to answer?

To determine how stimulation with different taste modalities alters the protein profiles of human whole and parotid saliva.

August 2, 2006Journal of Proteome ResearchOpen Access

Proteomic Analysis of Human Whole and Parotid Salivas Following Stimulation by Different Tastes

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Authors

ENEric NeyraudCentre National de la Recherche Scientifique TSThierry SaydUniversité Clermont Auvergne MMMartine MorzelInstitut Agro Rennes-Angers

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Implication

Proteomic study reveals taste-specific protein shifts in human saliva, indicating that inflammatory markers induced by bitter tastes originate from extra-parotid tissues.

Key Points

To determine how stimulation with different taste modalities alters the protein profiles of human whole and parotid saliva.
Collected human whole and parotid saliva samples following exposure to sweet, umami, bitter, and acid tastants.
Analyzed protein composition and changes using two-dimensional electrophoresis and mass spectrometry.
The number of salivary proteins altered by taste stimulation in whole saliva increased progressively in the order of sweet < umami < bitter < acid.
Annexin A1 and calgranulin A, both linked to inflammatory pathways, were over-represented in whole saliva following umami, bitter, and sour stimulations.
Annexin A1 and calgranulin A were absent or present in very low abundance in parotid saliva after bitter stimulation, indicating origin from non-parotid oral glands or mucosal tissues.

Cite This Study

Neyraud et al. (2006) studied this question.

synapsesocial.com/papers/6a721eb7a528af2d65c45126 https://doi.org/10.1021/pr060189z

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Implication

Proteomic study reveals taste-specific protein shifts in human saliva, indicating that inflammatory markers induced by bitter tastes originate from extra-parotid tissues.

Proteomic Analysis of Human Whole and Parotid Salivas Following Stimulation by Different Tastes

Discussion

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Implication

Key Points

Cite This Study

Proteomic Analysis of Human Whole and Parotid Salivas Following Stimulation by Different Tastes

Discussion

Member takes

Implication

Key Points

Cite This Study

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