Triple domino: An organocatalytic asymmetric triple cascade reaction to form tetracyclic pyridocarbazole derivatives is described. The new protocol includes a Diels–Alder/aza-Michael/aldol condensation sequence. Up to six stereogenic centers are formed with excellent diastereo- and enantioselectivity. IM = iminium activation; EN = enamine activation.
No takes yet. Share an insight, caveat, or question.
Enders et al. (2013) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: