Reversal of Rocuronium-Induced Neuromuscular Block with Neostigmine in the Libyan Patients

effective The use of two antagonists together is avoided as they are not additive and insufficient reversal can occur. Abstract Background: Reversal of the enduring effect of rocuronium by neostigmine is a common procedure performed in the Libyan hospitals. The reversal of the continuing effect of rocuronium by neostigmine was also evaluated. Methods: eighty adult surgical patients were included in the study using neostigmine 2.5mg (0.05-0.07mg/kg) to reversal the block induced by rocuronium 0.6 mg/kg. Anaesthesia was induced and maintained using i.v. propofol (2.5mg/kg) and fentanyl (1.5µg/kg). Reversal neuromuscular function was monitored using clinical signs includes patient responsiveness, subjective measurements of muscle strength (5 second head lift, hand grasp), eye opening, and tongue extrusion. Results: Reversal of block was sustained in all patients from the enduring effect of rocuronium by neostigmine. Ninety-six patients were had a similar time of recovery but eleventh were not. There were no serious adverse effects from neostigmine and no significant changes in any measure of safety. Conclusions: neostigmine is capable of reversing rocuronium-induced blockade in the Libyan patients by monitoring the muscle strength, eye opening, and tongue extrusion.