What question did this study set out to answer?

To examine the effects of the excitatory amino acid antagonist cis-2,3-piperidinedicarboxylic acid on cone signal transmission to second-order retinal neurons.

March 11, 1983Science

An Excitatory Amino Acid Antagonist Blocks Cone Input to Sign-Conserving Second-Order Retinal Neurons

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Authors

MSMalcolm M. SlaughterUniversity at Buffalo, State University of New York RMRobert F. MillerSmithsonian Institution

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Implication

Experimental study reveals cis-2,3-piperidinedicarboxylic acid reversibly blocks cone signals to OFF bipolars and horizontal cells, indicating a distinct postsynaptic receptor class.

Key Points

To examine the effects of the excitatory amino acid antagonist cis-2,3-piperidinedicarboxylic acid on cone signal transmission to second-order retinal neurons.
Administered the excitatory amino acid antagonist cis-2,3-piperidinedicarboxylic acid (PDA) to retinal preparations to observe cone-driven responses.
Tested the response to kainic acid in the presence of PDA to determine whether the antagonist acts via a postsynaptic mechanism.
PDA reversibly blocked cone input to OFF bipolar cells and horizontal cells, whereas ON bipolar cells remained relatively unaffected.
PDA blocked the physiological actions of kainic acid, confirming a postsynaptic site of action mediating cone signals in the outer retina.

Cite This Study

Slaughter et al. (1983) studied this question.

synapsesocial.com/papers/6a722596febe604dd70a7526 https://doi.org/10.1126/science.6131536

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Implication

Experimental study reveals cis-2,3-piperidinedicarboxylic acid reversibly blocks cone signals to OFF bipolars and horizontal cells, indicating a distinct postsynaptic receptor class.

An Excitatory Amino Acid Antagonist Blocks Cone Input to Sign-Conserving Second-Order Retinal Neurons

Discussion

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Implication

Key Points

Cite This Study

An Excitatory Amino Acid Antagonist Blocks Cone Input to Sign-Conserving Second-Order Retinal Neurons

Discussion

Member takes

Implication

Key Points

Cite This Study

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