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Adrenaline and noradrenaline induced dose related relaxations of the superfused rat colon. The relaxations were progressively transformed into contractions when beta-adrenoceptors were blocked with increasing doses of oxprenolol.2. Since phentolamine or phenoxybenzamine inhibited the contractions induced by adrenaline or noradrenaline in the presence of oxprenolol, it is assumed that the contractions are caused by stimulation of excitatory alpha-adrenoceptors.3. Human and rabbit taeniae coli showed responses that were qualitatively similar to those observed with the rat colon.
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Bélisle et al. (1971) studied this question.
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