Refractory urticarial dermatitis successfully treated with mycophenolate mofetil

Urticarial dermatitis is an uncommon inflammatory dermatosis characterized by persistent pruritic urticarial and eczematous eruptions associated with a dermal hypersensitivity reaction pattern on histopathology. We report a case of severe refractory urticarial dermatitis resistant to multiple therapies, including corticosteroids, cyclosporine, methotrexate, dapsone and azathioprine, which demonstrated significant clinical improvement following treatment with mycophenolate mofetil. This case highlights the diagnostic challenges of urticarial dermatitis and supports mycophenolate mofetil as a potential therapeutic option in refractory disease.