Prolonged high-dose cabergoline administration in a case of late-onset ovarian hyperstimulation syndrome

Ovarian hyperstimulation syndrome (OHSS) is a serious complication of controlled ovarian hyperstimulation which could be life-threatening. The present case is a patient at low risk for developing OHSS. She underwent a flexible antagonist protocol, followed by embryo transfer on day 3. She developed symptoms of abdominal pain, distension, and discomfort on the 7 th day after embryo transfer. She was diagnosed as moderate OHSS. Cabergoline 0.5 mg daily was started in addition to the standard treatment protocol for management of OHSS. On day 14 after embryo transfer, symptoms worsened following a positive pregnancy test. After this, cabergoline was stepped up to 1 mg/day. She was discharged, following complete resolution of her symptoms at 7 weeks of gestation. Cabergoline was withdrawn at discharge. Thus, in addition to the standard management protocol, prolonged high-dose cabergoline was required to help patient tide over OHSS and recover from it.