Mp45-05 looking Beyond Hypogonadism

INTRODUCTION AND OBJECTIVE: Men with low testosterone are routinely referred to urology clinics for intervention. It has been suggested that low testosterone is associated with metabolic syndrome, a harbinger for cardiac morbidity. Yet, this relationship remains unclear. The AUA guidelines state that ordering an HbA1c should be considered by urologists. Given the potential opportunity for earlier diagnosis of metabolic disorders among urologists, the goal of this study was to better define the relationship between low testosterone and metabolic syndrome. METHODS: The National Health and Nutrition Examination Survey (NHANES) database was queried for men between 19-59 years of age between the years of 2013-2016. We defined metabolic syndrome per the National Cholesterol Education Program (NCEP) ATP III criteria and hypogonadism as total testosterone < 300 ng/dl as defined by the AUA. Sample weights were applied for sampling and non-response bias. We compared demographic, clinical, hormone factors with chi square and t-tests, and then performed logistic regression. RESULTS: Among 3,350 men included in this study, 24% had testosterone < 300 and 26% had metabolic syndrome. Men with low testosterone were more likely to be older, have a higher BMI, higher HbA1c, lower HDL, higher triglycerides, higher fasting blood glucose, larger waistline, hypertension, and metabolic syndrome (p<0.001 for all). In the multivariate analysis, significant associations were seen between hypogonadism and large waistlines and low HDL (OR 4.32 p<0.001, OR 1.67 p=0.008 respectively). When stratifying by a younger age cohort (19-39), we found an even stronger association with larger waistline (OR 6.52 p <0.001). CONCLUSIONS: This study suggests that low testosterone is associated with risk factors of large waistline and low HDL among men 19-59 years old. Among young hypogonadal men, we identified an even stronger association with large waistline. Further studies are needed to better define the significance of this relationship and associations with metabolic syndrome. Source of Funding: none