In their Perspective "The future of genetic studies of complex human diseases (13 Sept., p. 1516), Neil Risch and Kathleen Merikangas emphasize that such studies might benefit greatly from approaches based on gametic disequilibrium. Recent genome scans (1) and our own data on human leukocyte antigen (HLA)-DRB1 gene in patients with multiple sclerosis (MS) illustrate the issue well.
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Yaouanq et al. (1997) studied this question.
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