Role of IL-17 gene polymorphisms in osteoarthritis: A meta-analysis based on observational studies

BACKGROUND: gene and the risk of OA in different populations have yielded conflicting findings. AIM: gene and the risk of OA. METHODS: We conducted a meta-analysis by systematically searching databases, including PubMed, EMBASE, MEDLINE, Cochrane Library, and Google Scholar to evaluate this association by calculating pooled odds ratios with 95% confidence intervals. Moreover, subgroup analyses stratified by ethnicity and OA type were also conducted. RESULTS: gene increased the risk of OA. Furthermore, stratification analyses by ethnicity and OA type showed that the rs2275913 polymorphism increased the risk of OA among Asians and in knee/hip OA, respectively. In addition, stratification analyses also revealed that the rs763780 polymorphism increased OA risk among both Asians and Caucasians in knee/hip OA. CONCLUSION: gene increased the risk of OA only among Asians. Due to the limitations of this study, these findings should be validated in future studies.