Circulating Vascular Growth Factors and Central Hemodynamic Load in the Community
Why the study?
Are circulating vascular growth factors associated with central hemodynamic load in a community-based cohort?
Population
3496 participants from the Framingham Heart Study third generation cohort, mean age 40±9 years, 52% women
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
These cross-sectional associations support hypothesis-generating research; leaves open causality and any clinical role in hypertension.
Structured PICO
Are circulating vascular growth factors associated with central hemodynamic load in a community-based cohort?
P
Population
3496 participants from the Framingham Heart Study third generation cohort, mean age 40±9 years, 52% women
I
Intervention
Circulating concentrations of vascular growth factors (angiopoietin 2, its soluble receptor; vascular endothelial growth factor, its soluble receptor; hepatocyte growth factor; insulin-like growth factor 1; and its binding protein 3)
O
Outcome
4 tonometry-derived measures of central arterial load (carotid femoral pulse wave velocity, forward pressure wave, mean arterial pressure, and global reflection coefficient)surrogate
Circulating vascular growth factors, particularly IGF-1 and VEGF, are associated with measures of central hemodynamic load in a community-based cohort.
Cite This Study
Zachariah et al. (2012) studied this question.