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What are the independent predictors and confounding factors for plasma MRproADM and MRproANP concentrations in healthy individuals?
What are the independent predictors and confounding factors for plasma MRproADM and MRproANP concentrations in healthy individuals?
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Age, BMI, gender, heart rate, and renal function independently influence plasma MRproADM and MRproANP concentrations in healthy individuals, highlighting the need to account for these confounders when using them as heart failure biomarkers.
BACKGROUND: MRproADM and MRproANP can be used as diagnostic and prognostic markers in heart failure. AIM: The objective was to identify confounding factors for the interpretation of plasma MRproADM and MRproANP concentrations. METHODS: A total of 518 healthy volunteers with a mean age of 60.84 ± 7.41 years were analyzed. We evaluated the influence of demographic factors, renal function and echocardiographic indices on the candidate peptides. RESULTS: Multivariate analysis revealed that age (P < 0.001), BMI (P < 0.001) and eGFR (P < 0.001) were independent predictors for MRproADM concentrations in healthy subjects. The independent predictors for MRproANP were age (P < 0.001), female gender (P < 0.001), heart rate (P < 0.001) and eGFR (P = 0.039). CONCLUSION: The interpretation of both peptides is multifaceted due to confounders. Knowledge of these factors will further our understanding of how these peptides behave in health and in disease.
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Bhandari et al. (2011) studied this question.
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