Pregnancy rates following three different timings of intrauterine insemination for women with unexplained infertility: A randomised controlled trial

Objective To compare pregnancy rates following three different timings of intrauterine insemination after human chorionic gonadotrophin administration at 24, 34 and 48h in women with unexplained infertility. Setting Kasr El-Aini Hospital. Design Randomized controlled trial. Participants and methods Couples with unexplained infertility had 125 cycles of IUI divided in three groups: Group (1) : 24h after hCG administration, Group (2) : 34h after hCG administration and Group (3) : 48h after hCG administration. Results There was no significant difference in pregnancy rates between all groups, Group 1 vs. Group 2 OR=0.61, 95% [CI] 0.15–2.36, Group 1 vs. Group 3 OR=0.42, 95% CI 0.12–1.53 and Group 2 vs. Group 3 OR=0.729, CI 0.23–2.32. Conclusion IUI can be done any time between 24 and 48h after hCG injection without significant differences in pregnancy rates.