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June 20, 2016Scientific ReportsOpen Access

CD8+ T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia

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Authors

JQJihua QiuQilu Hospital of Shandong UniversityXLXuena LiuBeijing Tongren HospitalXLXiaoqing LiSichuan University

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Qiu et al. (2016) studied this question.

synapsesocial.com/papers/6a723bd9fe4101aa97e0cc22https://doi.org/10.1038/srep27445
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Also Consider

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  1. 1Measurement of cytotoxic activity in experimental cancer2004 · 11 citations
  2. 2The Role of Sialic Acid in Determining the Survival of Glycoproteins in the Circulation1971 · 1,077 citations
  3. 3Interleukin 27 inhibits cytotoxic T-lymphocyte-mediated platelet destruction in primary immune thrombocytopenia2014 · 37 citations
  4. 4Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice2011 · 198 citations
  5. 5Role of sialic acid for platelet life span: exposure of β-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor–expressing liver macrophages and hepatocytes2009 · 222 citations