Comparative Study of Glucose and Fructose Metabolism in Infants With Reference to Utilization and to the Accumulation of Glycolytic Intermediates1

A number of studies of the comparative utiliza- tion2 of intravenously administered glucose and fructose have been carried out in adults (1-4). The results have almost uniformly favored fruc- tose, but have been concerned for the most part with infusions which were of short duration and quantitatively inadequate from the standpoint of caloric maintenance. The caloric equivalents of the differences in the excretion of the sugars were clinically insignificant.