Key result
Serum HBD activity accurately diagnoses myocardial infarction without requiring LDH isoenzyme separation.
Observational (n=330)
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THE SERUM LACTATE DEHYDROGENASE (LDH) has been much used for the diagnosis of myocardial infarction, but because of its lack of specificity it is often combined with isoenzyme studies.¹Of the five LDH isoenzymes, the electrophoretically fastest components, LDH₁and LDH₂, characteristic of heart muscle, are preferentially increased after myocardial infarction; we have shown²that these more readily reduce α-ketobutyrate than the slow-moving fractions, LDH₄and LDH₅found in the liver. This reduction of α-ketobutyrate has been termed "α-hydroxybutyrate dehydrogenase" (HBD) activity.³We have shown that determination of the serum HBD activity provides a useful diagnostic test for myocardial infarction and eliminates the need for isoenzyme separation.⁴,⁵As expected, raised serum HBD activities are not often encountered in liver diseases.⁶ The value of the new test has been confirmed.⁷⁻¹¹but as we have now had experience with it in 330
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Rosalki et al. (1964) conducted an observational in Myocardial infarction (n=330). Serum α-hydroxybutyrate dehydrogenase (HBD) activity determination vs. Serum lactate dehydrogenase (LDH) and isoenzyme separation was evaluated on Diagnosis of myocardial infarction. Serum α-hydroxybutyrate dehydrogenase (HBD) activity determination across 330 cases provided a useful diagnostic test for myocardial infarction without requiring LDH isoenzyme separation.
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