Summary and Conclusions A technique is described for the examination of thin plasma clots with the electron microscope, by which the clots of nine patients with classical hemophilia and five normal controls were studied. The hemophiliacs’ plasma clots were strikingly different from normal, with relatively straight, wide fibrin strands. This difference appeared to be due to their long clotting times. It is proposed that this abnormal end-product of fibrin polymerization in hemophilia, perhaps together with the decreased platelet clumping which also was observed, may be a cause of the functional inadequacy of blood clots in hemophilia. Presented in part in abstract, Clinical Research 11: 190, 1963 and clinical Research 11: 293, 1963.
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Bettigole et al. (1964) studied this question.