The influence of acute changes in systemic hemodynamics on the rate of oxygen utilization by the left ventricle has been studied in intact anesthetized dogs. Certain types of hemodynamic changes caused reproducible alterations in the relationship between oxygen consumption of the left ventricle and its external mechanical work. The relationship of left ventricular minute oxygen consumption to the product of mean systolic aortic pressure and systolic ejection period per minute was constant over an extreme range of varied types of hemodynamic alterations. Changes in oxygen consumption were proportionately less than concomitant changes in heart rate. These findings are in accord with previous studies of isolated heart preparations.
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Neill et al. (1963) studied this question.
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