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Reports bleeding diathesis from lupus anticoagulant-hypoprothrombinemia syndrome in two young females, highlighting the necessity of early diagnosis to prevent fatal complications.
Lupus anticoagulant (LA)-hypoprothrombinemia syndrome is a combination of acquired factor II (FII) deficiency and LA. Herein, we report two young females presenting with a clinical history of menorrhagia, epistaxis, and gum bleeding with prolonged prothrombin time and activated partial thromboplastin time. The inhibitor screen suggested the presence of an immediate-acting inhibitor; tests for the presence of LA were positive. Factor assays performed showed low FII levels. Early diagnosis of this entity is crucial as it results in fatal complications due to bleeding.
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Thambiraj et al. (2025) studied this question.
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