Key result
Cardiopulmonary bypass and cardioplegia induce systemic microvascular dysfunction, impairing endothelial tone and organ perfusion.
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Review highlights microvascular dysfunction after cardioplegia and cardiopulmonary bypass, indicating potential drivers of organ malperfusion and tissue damage.
Cardioplegia and cardiopulmonary bypass (CP/CPB) during cardiac surgery may cause systemic microvascular dysfunction.CP/CPB is associated with significant alterations in myogenic tone, agonist-induced vasomotor response, and endothelial function in various organs and vascular beds.These alterations can result in vessel spasm, organ malperfusion, and tissue damage.This review summarizes the current state of research in this field.
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Feng et al. (2021) conducted a review in Microvascular dysfunction following cardiac surgery. Cardioplegic arrest and cardiopulmonary bypass (CP/CPB) was evaluated on Systemic microvascular dysfunction, vessel spasm, organ malperfusion, and tissue damage. Cardioplegia and cardiopulmonary bypass during cardiac surgery cause systemic microvascular dysfunction, altering myogenic tone and endothelial function to induce organ malperfusion.
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