A chip for single mismatches: Results obtained with a photochemical-ligation-based DNA chip for enhanced discrimination of single-nucleotide polymorphisms (see scheme) show that the reaction takes place over a period of hours, with the 50 % stage reached within 10 minutes. A single mismatch in the target sequence yielded extremely little ligated product (a rate 103-fold lower than for the complementary case).
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Ogasawara et al. (2006) studied this question.
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