This study identifies TLR8 and TLR7 as the primary host sensors for human parechovirus 1, providing insight into the innate immune response to this ssRNA virus.
Answers are grounded in this paper and cite their sources.
Animal models implicate TLR7/8 in parechovirus sensing; leaves open human relevance and therapeutic targeting.
Toll-like receptors (TLR) have a key role in regulating immunity against microbial agents. Engagement of TLR by bacterial, viral or fungal components leads to the production and release of inflammatory cytokines. In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human parechovirus 1, a single-stranded RNA (ssRNA) virus. Furthermore, we see that the viral ssRNA genome is detected in endosomal compartments by these TLR, which activate signalling that lead to the synthesis of pro-inflammatory molecules by the host.
No takes yet. Share an insight, caveat, or question.
Triantafilou et al. (2005) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: