Difficulties previously encountered in the very useful "click" functionalization of gold nanoparticles (AuNPs) resulting in low yields are now overcome by using specific conditions: 1:1 water-THF medium, stoichiometric CuSO(4) and sodium ascorbate, inert atmosphere at 20 degrees C that provide quantitative "click" reactions between azidoalkylthiolate-AuNPs with various hydrophilic (PEG-containing) and hydrophobic (organic and organometallic) alkynes.
No takes yet. Share an insight, caveat, or question.
Boisselier et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: