Objective To explore the anti-fertility efficacy of aqueous-ethanolic (1:1) extract of fruits of Terminalia chebula ( T. chebula ). Methods Aqueous-ethanolic (1:1) extract of fruit of T. chebula was administered orally at a dose of 60 mg/0.5 mL distilled water/day for 28 days. Different parameters were studied including body weight, relative weight of reproductive organ, sperm motility, sperm count, testicular cholesterol, plasma testosterone, testicular androgenic key enzymes such as Δ 5 , 3β-HSD and 17-β-HSD, bio-markers of oxidative stress, toxicity study and histological analysis of the tissues. Results The treated group showed a significant diminution in spermatogenic profile. On the other hand testicular cholesterol showed a significant elevation in T. chebula treated group and plasma testosterone was decreased significantly in comparison to control. The above said androgenic key enzymes were exerted a significant diminution in extract treated group. Anti-oxidative enzymes such as catalase and superoxide dismutase showed a significant reduction and a significant elevation in conjugated diene and Thiobarbituric acid reactive substance was noted in treated group. GOT and GPT study of liver and kidney showed a non-significant change which confirmed the non-toxic nature of T. chebula . Histological study of testis of treated group exhibited significant reduction in seminiferous tubular diameter. Conclusion The results of present experiment suggested that the aqueous-ethanolic (1:1) extract of fruit of T. chebula exerted a significant anti-spermatogenic effect in male rat.
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Ghosh et al. (2015) studied this question.
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