By 2050, an estimated 1.5 million people in the United States will be living with a major lower-limb amputation [1], a condition that causes severe disability, particularly for persons with transfemoral (above-knee) amputations. These individuals expend up to twice the metabolic effort to walk at half the speed [2] of able-bodied persons, and they experience a higher risk of falls and secondary pathological conditions, such as osteoarthritis, back pain, and depression [3].
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Lenzi et al. (2014) studied this question.