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April 17, 2017The Journal of Clinical Endocrinology & MetabolismOpen Access

The FAT Score, a Fibrosis Score of Adipose Tissue: Predicting Weight-Loss Outcome After Gastric Bypass

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Why the study?

Does the FAT score predict poor weight-loss response in severely obese patients undergoing Roux-en-Y gastric bypass?

Population

183 severely obese patients who underwent Roux-en-Y gastric bypass, including a training cohort and a…

Design

Cohort

Follow-up

1 year

Authors

PLPierre Bel LassenInsermFCFrédéric CharlotteSorbonne UniversitéYLYuejun LiuHebei University of Engineering

Discussion

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Implication

May identify poor bariatric surgery responders via scAT fibrosis score; leaves open prospective validation before clinical use.

Structured PICO

Does the FAT score predict poor weight-loss response in severely obese patients undergoing Roux-en-Y gastric bypass?

P
Population
183 severely obese patients who underwent Roux-en-Y gastric bypass (RYGB), including a training cohort (n=85) and a confirmation cohort (n=98).
I
Intervention
Fibrosis score of adipose tissue (FAT score) evaluating subcutaneous adipose tissue (scAT) fibrosis from perioperative biopsy specimens.
O
Outcome
Poor weight-loss response (PR) to RYGB, defined as <28% of total weight loss at 1 year.surrogate

The FAT score is a simple, semiquantitative tool that can predict limited weight-loss response to Roux-en-Y gastric bypass in severely obese patients.

Cite This Study

Lassen et al. (2017) studied this question.

synapsesocial.com/papers/6a7255ab35aa2c282ce33428https://doi.org/10.1210/jc.2017-00138
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