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Excellent chemical and optical yields (>96% retention) of cyanides are achieved by vapor phase thermolysis or short contact flow thermolysis of isocyanides. trans ‐2‐Butenyl isocyanide rear‐ranges without concomitant allylic isomerization to trans ‐2‐butenyl cyanide. Optically active 1‐(formyloxymethyl)‐2‐phenylethyl cyanide is obtained from optically active L ‐phenylalanine as a new type of chiral pool synthon.
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Meier et al. (1987) studied this question.
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