The Study of Tacrolimus-Loaded Polyion Complex Micelles for Oral Delivery

) of FK506 in F127-CS/NaDC micelles decreased from 3 to 1 h and the half-life was prolonged from 16.09 h to 18.00 h. Moreover, drug-time area under the curve was increased by 39.3%, from 533.79 to 742.11 ng/mL·h, which indicated enhanced oral absorption of FK506 in FK506-loaded F127-CS/NaDC micelles. Furthermore, the immunosuppressive effect of FK506-loaded F127-CS/NaDC micelles in a rat liver transplantation model was better than that of FK506 solution. All these results showed that FK506-loaded F127-CS/NaDC micelles are a promising approach for oral delivery of FK506.