The macrobicyclic polyether (1) is the first “small” model system which exhibits a binding cooperativity. It could be shown by 600-MHz 1H-NMR studies that binding of one Hg(CN)2 to (1) increases its binding ability for a second Hg(CN)2 by a factor of ten.
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Rebek et al. (1981) studied this question.
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