Abnormal Skeletal Mineral Metabolism in Sarcoidosis

Article1 April 1966Abnormal Skeletal Mineral Metabolism in SarcoidosisJAMES Z. HENDRIX, M.D.JAMES Z. HENDRIX, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-4-797 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn sarcoidosis, abnormalities of calcium, magnesium, and phosphorus metabolism (1-20) have been reported. There are conflicting reports (5, 12, 17-26) as to the pathogenesis and the sites of involvement.It has been suggested that the abnormal mineral metabolism could be due to excessive endogenous production of vitamin D (5), abnormal metabolism of vitamin D (20), or a "hypersensitivity" to vitamin D (23, 24) in gut, bone, and kidney. Cortisone (5, 12, 20, 22), adrenocorticotrophic hormone (27, 28), and chloroquine (29, 30) have been reported to be of therapeutic value in this disorder, whereas vitamin D (9, 12, 23, 25) and...References1. LONGCOPEFREIMAN WTDE: A study of sarcoidosis. Medicine (Balt.) 31: 1, 1952. CrossrefMedlineGoogle Scholar2. DENTFLYNNNABARRO CEFVFD: Hypercalcaemia and impairment of renal function in generalized sarcoidosis. Brit. Med. J. 2: 808, 1953. CrossrefMedlineGoogle Scholar3. ANDERSONDENTHARPERPHILPOT JCECGR: Effect of cortisone on calcium metabolism in sarcoidosis with hypercalcaemia. Lancet 2: 720, 1954. CrossrefGoogle Scholar4. GLECKLER WJ: Hypercalcemia and renal insufficiency due to sarcoidosis: treatment with cortisone. Ann. Intern. Med. 44: 174, 1956. LinkGoogle Scholar5. HENNEMANDEMPSEYCARROLLALBRIGHT PHEFELF: The cause of hypercalciuria in sarcoid and its treatment with cortisone and sodium phytate. J. Clin. Invest. 35: 1229, 1956. CrossrefMedlineGoogle Scholar6. 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Public Health Service, Washington, D. C.Requests for reprints should be addressed to James Z. Hendrix, M.D., Rockefeller University, New York, N. Y. 10021.*The formula was provided by E. H. Ahrens, M.D., Rockefeller University, New York, N. Y. 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ROBERT ARNSTEIN, M.D., BOY FRAME, M.D., F.A.C.P., HAROLD M. FROST, M.D.Coexistent Sarcoidosis and Hyperparathyroidism 1 April 1966Volume 64, Issue 4Page: 797-805KeywordsBone and mineral metabolismCalciumExcretionMagnesiumMedical servicesPathogenesisPhosphorusResearch facilitiesSarcoidosisVitamin D Issue Published: 1 April 1966 PDF DownloadLoading ...