Why the study?
Canagliflozin extends lifespan and provides neuroprotection specifically in male mice at 180 ppm despite higher drug accumulation in females, raising the question of whether a reduced dose of 60 ppm provides neuroprotective benefits in females.
Does canagliflozin at 60 ppm improve neuroprotection in aging male and female UM-HET3 mice?
Does canagliflozin at 60 ppm improve neuroprotection in aging male and female UM-HET3 mice?
Canagliflozin exhibits fundamental sex differences in biological response and neuroprotection in aging mice, which are not solely driven by dose or drug accumulation.
Answers are grounded in this paper and cite their sources.
Sex differences in canagliflozin response in aging mice are not explained by drug levels alone; leaves open mechanisms and human applicability.
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Manchanayake et al. (2026) studied Aging. Canagliflozin was evaluated on Cognitive function and neuroinflammation.
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