Why the study?
Does experimental cardiac infarction alter tolerance to digitalis in animal models?
Population
Cats and dogs with experimental cardiac infarction (extensive ligation of coronary vessels)
Comparison
Ouabain or digitalis vs Normal animals without coronary occlusion
Design
Preclinical
Follow-up
Up to 6 months
Authors
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Alerts to possible digitalis sensitivity in experimental post-MI models; leaves open human translation and dose guidance.
Does experimental cardiac infarction alter tolerance to digitalis in animal models?
Experimental cardiac infarction reduces tolerance to digitalis in the subacute phase (4 days) with partial recovery over months in animal models.
Janet Travell (1938) studied this question.
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