A 39-yr-old male with hypopituitarism following severe head trauma at age 4 is described. Clinical and laboratory studies revealed deficiencies of gonadotropin, thyrotropin and corticotropin and partial deficiency of vasopressin secretion. Serum growth hormone was detectable but failed to rise in response to insulininduced hypoglycemia. Despite severe hypopituitarism, he attained a height of 63¾ inches. These observations and the probable site of the lesion are discussed in light of present concepts of regulation of anterior pituitary function by the hypothalamus.
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Klachko et al. (1968) studied this question.