September 10, 2007CirculationOpen Access

Differential Protein Kinase C Isoform Abundance in Ascending Aortic Aneurysms From Patients With Bicuspid Versus Tricuspid Aortic Valves

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Population

133 patients, including those with ascending thoracic aortic aneurysms and bicuspid aortic valves, ATAAs and…

Design

Cross-sectional

Authors

JJJeffrey A. JonesMichael E. DeBakey VA Medical Center RSRobert E. StroudCardiac Surgery BKBrooke S. Kaplan

Discussion

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Implication

Supports distinct PKC pathways in BAV- versus TAV-associated aortopathy; hypothesis-generating and does not yet inform clinical management.

Structured PICO

Population

133 patients, including those with ascending thoracic aortic aneurysms (ATAAs) and bicuspid aortic valves (BAV, n=57), ATAAs and tricuspid aortic valves (TAV, n=55), and a nonaneurysmal control group (n=21).

Outcome

Abundance of 10 different PKC isoforms assessed by immunoblottingsurrogate

Differential PKC isoform abundance in ascending aortic aneurysms suggests independent molecular signaling pathways drive aneurysm formation in patients with bicuspid versus tricuspid aortic valves.

Cite This Study

Jones et al. (2007) studied this question.

synapsesocial.com/papers/6a7265b4a7fbea1e4408a917 https://doi.org/10.1161/circulationaha.106.681361

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Implication

Supports distinct PKC pathways in BAV- versus TAV-associated aortopathy; hypothesis-generating and does not yet inform clinical management.

Differential Protein Kinase C Isoform Abundance in Ascending Aortic Aneurysms From Patients With Bicuspid Versus Tricuspid Aortic Valves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differential Protein Kinase C Isoform Abundance in Ascending Aortic Aneurysms From Patients With Bicuspid Versus Tricuspid Aortic Valves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider